Poison synergies

Everything related to Poison. Combine a "generates" entry with a "reacts" entry for a synergy (classified automatically from description wording, so the occasional entry may be misfiled).

ShardsStallRushShieldsPoisonBurnFrostCritHealingDebuffsStealthStun

Poison is a debuff dealing damage equal to its stacks every 2 seconds. It does not decay on its own, so every stack keeps weighing on the target.

Stack it with appliers like Skorn and Pimenta, then accelerate with reactors keyed to Poison application or amount. As a debuff it benefits from all debuff amplifiers, and its total damage grows with fight length — a natural partner for Stall comps.

Generates Poison (29)

Heroes (3)

ZuriPetrification

Petrify all enemies targeting Zuri, dealing 150 + 250% Magic damage, inflicting 1 Poison per Stone Skin trigger this game, and Stunning for 4 seconds.

SkornRetribution

When auto attacked after Stall (10), deal 2 + 100% Magic damage and inflict 2% Defense Poison on the attacker.

PimentaPepper Spray

Create a poison cloud around Pimenta for 4 seconds.

Each second, deal 5 + 50% Magic + 50% Defense damage and inflict 2 + 4% Defense Poison to enemies in the poison cloud.

Each second after Stall (15), gain 3 + 2×Rank HP/S per enemy in the poison cloud.

Specializations (6)

The NightshadeYuuna

Shuriken Shadow Strike gains +150% Crit against Poisoned enemies.

Whenever an Assassin Crits, they inflict 4 + 4×Rank Poison. Backup.

The CruelZuri

Petrify all enemies targeting Zuri, dealing 150 + 250% Magic damage, inflicting 1 Poison per Stone Skin trigger this game, and Stunning for 4 seconds.

The SparkNyx

After Stall (10), each auto attack inflicts 2 + 3.3% Attack Speed Burn.
After Stall (20), each auto attack inflicts 1 + 2.5% Attack Speed Frost.
After Stall (30), each auto attack inflicts 2% Attack Speed Poison.

The Fae's KissPollen

After Stall (20), Sanctuary of Bloom inflicts 100% more Poison.

After Stall (40), increase the amount of Debuffs on all enemies by 33 + 33×Rank%. Backup.

The Winter's BiteSkorn

Whenever Skorn inflicts Poison, he inflicts an equal amount of Frost.


Whenever Skorn inflicts Frost, he gains 10×Rank Shields.

The BristleguardSkorn

At start of combat, for each Tank in combat inflict 5 + 10×Rank Poison on all enemies and give 5 + 10×Rank Defense to all Heroes. Backup.

Items (4)

Toxic DartRare

On Crit, inflict 3 Poison.

Venomous GauntletsEpic

On auto attack, inflict 1 Poison on the target.
When auto attacked, inflict 1 Poison on the attacker.

Toxic ShivUnique

On Crit, inflict 1 Poison.

Toxic GauntletUnique

Every 3 times the holder is auto attacked, inflict 1 Poison on the attacker.

Relics (13)

Poison BloomCommon

After Stall (10 and Stall 20), inflict 10 Poison on all enemies.

Plague GeneratorCommon

At start of combat, inflict 5 Poison, 10 Frost, and 15 Burn on all enemies.

Tank's MementoRare

At start of combat, inflict 20 Poison on all enemies per Tank in combat.

Poison AmplifierRare

Whenever a Hero inflicts Poison, inflict 33% more.

Duelist's Rhythm PrismEpic

Whenever a Duelist auto attacks, they randomly inflict 2 Poison, 4 Frost, or 6 Burn on their target.

Tank's Poisonplate BannerUnique

Whenever a Tank is auto attacked, they apply 1 Poison to the attacker.

Duelist's Toxin BannerUnique

Whenever a Duelist auto attacks, they inflict 1 Poison on their target.

Poison BaubleUnique

At start of combat, inflict 5 Poison on all enemies.

Plague BaubleUnique

At start of combat, inflict 3 Poison, 6 Frost, and 9 Burn on all enemies.

Assassin's Ambush EngineLegendary

Heroes gain 30 Crit.

Whenever an Assassin auto attacks while Stealthed, they inflict Poison on their target equal to 75% of their Crit.

At start of combat, Assassins in the back 2 rows gain Stealth for 5 seconds and target the most threatening enemy.

Plague Transmission EngineLegendary

At start of combat and every 10 seconds, inflict 10 Poison, 20 Frost, and 30 Burn on all enemies.

The Fairy RingSingle Battle Boost

At start of combat, inflict Poison on all Heroes equal to 1% of their Max HP.

Get woundedHawkItemId when this expires.

Poison Dragon's VenomAct Boss

At start of combat, inflict act2ActBossStacks Poison on all Heroes.
On combat victory, permanently increase the amount of Poison this inflicts by 2.

Rank upgrades (3)

Poisonous PresenceTank / rank A・S

Tanks gain +33% Defense against damage from enemies with Poison. Backup.

Poisonous EdgeAssassin / rank A・S

Gain +50% Crit against enemies with Poison.

Poisonous EyeAssassin / rank A・S

At start of combat, inflict 10 + 25% Crit Poison on all enemies.

Reacts to Poison (10)

Items (1)

Ring of the LeechEpic

Whenever an enemy takes Poison damage, gain 1 Crit and 1 HP/S.

Relics (7)

Poison CatalystRare

After Stall (15), whenever an enemy with Poison is auto attacked, they take damage equal to their Poison.

Deceleration CorruptorEpic

After Stall (15) and Stall (30), double the amount of Poison on all enemies.

Venom Precision PrismEpic

Whenever an enemy takes Poison damage, Heroes gain 2 Crit.

Poison MigratorEpic

Whenever an enemy dies, transfer their Poison to the nearest enemy.

Blight Resonance PrismEpic

Whenever an enemy takes Poison or Burn damage, heal all adjacent Heroes to them for 50% of that damage.

Venom Amplification EngineLegendary

Whenever an enemy takes 50 or more damage from Poison, they also take damage equal to 4% of their Max HP.

Poison Dragon's VenomAct Boss

At start of combat, inflict act2ActBossStacks Poison on all Heroes.
On combat victory, permanently increase the amount of Poison this inflicts by 2.

Rank upgrades (2)

Poisonous RestorationTank / rank A・S

When auto attacked by an enemy with Poison, gain 2 HP/S.

Poisonous AccelerationDuelist / rank A・S

Whenever a Duelist attacks an enemy with Poison, they gain 2 Attack Speed. Backup.

Other mentions (5)

Heroes (1)

PollenSanctuary of Bloom

Create a flower field for 5 seconds.

Each second, inflict 1 + 12.5% Mana Regen Poison on enemies and apply 10 + 100% Magic Shields to Heroes inside the flower field.

Each second after Stall (15), heal Heroes inside the flower field for 10 + 50% Magic.

Specializations (1)

The Serpent's KissZuri

When auto attacked, inflict 1 + 1.7% Defense + 2% Magic Poison on the attacker and gain 1×Rank HP/S.

Rank upgrades (3)

Poisonous AuraTank / rank A・S

When auto attacked, inflict 1 + 0.4% Defense Poison on the attacker (Max: 3).

Poisonous BurstAssassin / rank A・S

On Crit, inflict 1 + 6.7% Crit Poison on the target.

Poisonous AttacksDuelist / rank A・S

On auto attack, inflict 1 + 0.8% Attack Speed Poison (Max: 3).