Debuffs synergies
Everything related to Debuffs. Combine a "generates" entry with a "reacts" entry for a synergy (classified automatically from description wording, so the occasional entry may be misfiled).
Poison, Frost and Burn are collectively treated as "debuffs" — that trio is the in-game definition.
Amplifiers of debuff application (like Aria's specialization) boost all three at once, so comps spreading several debuffs profit most. Effects growing per application (Sal) complete the ideal three-step shape: spread, amplify, react.
Generates Debuffs (12)
Specializations (3)
The ResplendentAria
Mages inflict 20 + 10×Rank% more Debuffs. Backup.
Aria inflicts an additional 50% more Debuffs.
The SpicyPimenta
On auto attack, for each type of Debuff on the target inflict 2 + 1×Rank more of that Debuff and deal 10 + 75% Attack Speed bonus damage.
The BreezySal
Whenever a Mage or Duelist inflicts a Debuff, they gain 1×Rank Attack Speed and 1 + 1×Rank Magic. Backup.
Items (1)
Plague AmuletRare
On cast, gain 4 Magic per type of Debuff on all enemies.
Relics (5)
Plague HarvesterRare
After Stall (15), Heroes gain 1 Defense and 1 Magic per 25 Debuffs on all enemies.
Plague AmplifierRare
For Rush (12), if an enemy would gain a Debuff they gain 1 more.
Plague AcceleratorEpic
For Rush (12), if an enemy would gain a Debuff they gain 2 more.
Plague VelocitizerEpic
Every 4 seconds, Heroes gain 1 Attack Speed and 2 Attack per type of Debuff on all enemies.
Mystic's Outbreak BannerUnique
Whenever a Mystic casts, they gain 2 Magic per type of Debuff on all enemies.
Rank upgrades (3)
Debuff VelocityDuelist / rank A・S
On auto attack, gain 1 Crit and 1 Attack per Debuff on the target.
Debuff ChannelingMystic / rank A・S
On cast, gain 1 Mana Regen for each type of Debuff on all enemies.
Debuff ProtectionMystic / rank A・S
On cast, give the lowest percent health Hero 1 Shield per 2 Debuffs on all enemies.
Reacts to Debuffs (7)
Specializations (2)
The Fae's KissPollen
After Stall (20), Sanctuary of Bloom inflicts 100% more Poison.
After Stall (40), increase the amount of Debuffs on all enemies by 33 + 33×Rank%. Backup.
The SpicyPimenta
On auto attack, for each type of Debuff on the target inflict 2 + 1×Rank more of that Debuff and deal 10 + 75% Attack Speed bonus damage.
Items (3)
Cleansing CharmEpic
Every 5 seconds, remove 33% of all Debuffs from the holder.
Infectious BowUnique
Whenever the holder inflicts a Debuff, inflict 1 more.
Infectious GauntletUnique
Whenever the holder inflicts a Debuff, inflict 1 more.
Relics (1)
Duelist's Outbreak BannerUnique
Whenever a Duelist auto attacks, they gain 1 Attack Speed and 1 Attack per type of Debuff on their target.
Rank upgrades (1)
Debuff AmplificationMystic / rank A・S
On cast, increase the amount of each Debuff on enemies in range by 50% Mana Regen.
Other mentions (1)
Relics (1)
Mystic's Protection BannerUnique
Whenever a Mystic casts, they Shield the nearest Hero equal to the total number of Debuff stacks on all enemies.